A nasal omicron vaccine booster elicits potent neutralizing antibody response against emerging SARS-CoV-2 variants비강 오미크론 백신 부스터는 새로운 SARS-CoV-2 변이체에 대한 강력한 중화 항체 반응을 이끌어냅니다.Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] absence adjuvants administration antibody Antibody Response boost booster Bronchoalveolar lavage caused clinical trial composed COVID-19 COVID-19 pandemic current deaths delta variant described disease severity domain dose effective Elevation elicit evidenced FIVE fused human infection human infections humans IgA Immunity immunogen intranasal leads mice MOST mucosal nasal nasal protein vaccine booster Neutralizing activity neutralizing antibody Neutralizing antibody response omicron Omicron variant omicron variant. Protein Receptor binding domain reduce respiratory SARS-CoV-2 SARS-CoV-2 nucleoprotein SARS-CoV-2 spike SARS-CoV-2 transmission SARS-CoV-2 variant severity significantly single dose suggested the antibody response the disease vaccination Vaccine virus infection wild-type [DOI] 10.1080/22221751.2022.2053365 PMC 바로가기 [Article Type] Article
The spectrum of clinical biomarkers in severe malaria and new avenues for explorationArticle Published on 2022-12-012022-11-15 Journal: Virulence [Category] 바이오마커, [키워드] Biomarker Biomarkers C-reactive protein clinical evaluation clinical infections Clinical practice complement COVID-19 pandemic diagnostic Endemic Evidence Factor faster highlight host response Infection infections malaria MOST non-specific omics technology pathogen patients Plasmodium Plasmodium falciparum Platelet Pneumonia practicality Prognosis prognostic Prognostic biomarkers Protein public health Research Sample size severe malaria the disease therapeutic therapeutic. [DOI] 10.1080/21505594.2022.2056966 PMC 바로가기
COVID-19 intranasal vaccines: current progress, advantages, prospects, and challengesCOVID-19 비강내 백신: 현재 진행 상황, 이점, 전망 및 과제Review Published on 2022-11-302022-09-12 Journal: Human vaccines & immunotherapeutics [Category] MERS, SARS, 진단, [키워드] added Administered administration Antibody Response Cell-mediated immunity cellular immunity country COVID-19 COVID-19 pandemic COVID-19 vaccine disease highlight immune response Immunity induce injected injection intramuscular intranasal intranasal vaccine limit MOST mucosal mucosal immunity. Multiple nasal pandemic Prevent Protective Replication robust SARS-CoV-2 SARS-CoV-2 vaccine secretory IgA shown stimulate Vaccine Vaccines virus infection virus transmission [DOI] 10.1080/21645515.2022.2045853 PMC 바로가기 [Article Type] Review
Preparing for pandemics: a systematic review of pandemic influenza clinical management guidelinesArticle Published on 2022-11-072022-11-15 Journal: BMC Medicine [Category] 치료제, [키워드] addressed AGREE II Antiviral treatment appraisal benefit Care children clinical Clinical management Clinical management guidelines COVID-19 pandemic evaluate Evidence guideline help heterogeneous highlight identify Immunosuppression implementation Influenza International management management guideline median morbidity and mortality MOST neuraminidase inhibitor New Older outcomes OVID oxygen pandemic Patient populations Practice pregnant women preparedness Preparing produced recommendation reduce Research risk searched Support supportive care supportive care. systematic review therapy Treatment Trial Turning [DOI] 10.1186/s12916-022-02616-6 PMC 바로가기
Acquired Thrombotic Thrombocytopenic Purpura After BNT162b2 COVID-19 Vaccine: Case Report and Literature ReviewArticle Published on 2022-11-032022-11-15 Journal: Laboratory medicine [Category] 진단, [키워드] Acquired ADAMTS Anemia autoantibody Blood BNT162b2 BNT162b2 vaccine caplacizumab caused Complete COVID-19 COVID-19 vaccine deficiency Diagnosis gastrointestinal symptoms immunosuppressive literature microangiopathy MOST occurred outcome Patient patients Pfizer-BioNTech plasma positive Prednisone presenting report reported review second dose significantly the patient therapy thrombocytopenia thrombosis thrombotic Thrombotic thrombocytopenic purpura treated Treatment Vaccine vaccine. was used [DOI] 10.1093/labmed/lmac016 PMC 바로가기
Genetic and immunologic evaluation of children with inborn errors of immunity and severe or critical COVID-19Article Published on 2022-11-012022-11-15 Journal: The Journal of Allergy and Clinical Immunology [Category] SARS, 진단, 치료기술, [키워드] acute respiratory syndrome Affect antibodies Asymptomatic autoantibody B-cell function children children with COVID-19 complement Complication complications coronavirus coronavirus disease COVID-19 COVID-19 complications COVID-19 disease Critical detectable develop diagnosed Diagnostic Criteria died disease evaluated Genetic genetic cause genetic diagnosis help hypoxemic IFN signaling IFN-I immune immune response Immunity immunodeficiency Inborn error inborn errors of immunity individual infected with SARS-CoV-2 Infection Inflammasome Inflammatory Inflammatory factor Mild Molecular diagnosis Mortality mortality rate MOST multisystem inflammatory syndrome in children (MIS-C) Mutation Neutralizing Patient patients patients with asymptomatic Pediatric patients plasma Pneumonia primary immunodeficiency. reported SARS-CoV-2 SARS-CoV-2-specific antibodies severe COVID-19 disease syndrome tested Treatment Type I IFN was performed were measured whole-exome sequencing [DOI] 10.1016/j.jaci.2022.09.005 PMC 바로가기
Deep immunophenotyping reveals biomarkers of multisystemic inflammatory syndrome in children in a Latin American cohortArticle Published on 2022-11-012022-11-15 Journal: The Journal of Allergy and Clinical Immunology [Category] SARS, 바이오마커, 진단, [키워드] acute respiratory syndrome Biomarker Biomarkers CCL5 Cell cellular response characterized chemokine children Chilean clinical clinical feature Cohort Complication convalescent coronavirus COVID-19 CXCL10 CXCL8 Cytokine storm deep degranulation disease dysregulation elevated enzyme-linked immunosorbent enzyme-linked immunospot flow cytometry gastrointestinal involvement humoral identify IL-10 IL-18 IL-6 immune dysregulation immune response Immunity Inflammation Inflammatory intestinal inflammation laboratory biomarker Latin life-threatening Ligand MIS-C mononuclear cell MOST motif multisystemic multisystemic inflammatory syndrome in children. natural killer neutralizing antibody neutralizing antibody assays NK cell NK cell deficiency occur organ Patient patients predict representing reveal robust severe multisystemic severity Shock significantly stools susceptibility sustained syndrome T-cell activation underlie was increased was performed [DOI] 10.1016/j.jaci.2022.09.006 PMC 바로가기
Evaluation of the impact of pre-analytical conditions on sample stability for the detection of SARS-CoV-2 RNAArticle Published on 2022-11-012022-11-15 Journal: Journal of virological methods [Category] SARS, 치료기술, 치료제, [키워드] collected Community condition conditions cycle threshold Demand Diagnosis diagnostics False negative increase in independent Laboratory MOST PBS postal service provide RNA RNA extraction RT-qPCR Sample Sample stability. SARS-CoV-2 SARS-CoV-2 E gene SARS-CoV-2 RNA sensitivity stability Swab temperature tested Transport media transported Variation Viral load VTM [DOI] 10.1016/j.jviromet.2022.114607 PMC 바로가기
Geographical distribution of SARS-CoV-2 amino acids mutations and the concomitant evolution of seven distinct clades in non-human hostsArticle Published on 2022-11-012022-11-16 Journal: Zoonoses and Public Health [Category] COVID19(2023년), SARS, 변종, [키워드] Amino acid analysed Analysis antigenicity clade Combination country Denmark distribution early stage Efficacy epidemiological Evolution exhibiting GISAID globe Host human SARS-CoV-2 indicate Latvia Local moderate MOST Mutation mutations Netherlands Non-human Non-human hosts ORF10 ORF3a pandemic pathogenicity Proteome evolution raised SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2. sequence Seven Surveillance sustained the SARS-CoV-2 genome the vaccine Transmissibility transmissions USA variant viral evolution Viral transmission viral variant Whole-genome sequence zoonotic zoonotic transmission [DOI] 10.1111/zph.12971 PMC 바로가기
Population-based hospitalization burden estimates for respiratory viruses, 2015-2019Article Published on 2022-11-012022-11-15 Journal: Influenza and Other Respiratory Viruses [Category] 치료기술, [키워드] Adenovirus age ARI burden calculate coronavirus Coronaviruses cost eligible EMR estimate female health system hospital hospital discharge Hospitalization hospitalizations illness include increasing age Influenza influenza A influenza B métapneumovirus MOST parainfluenza Patient Pittsburgh public health ranged Research respiratory infection respiratory syncytial virus respiratory viral infections respiratory viral infections. respiratory virus respiratory viruses responsible rhinoviruses RSV The United States virus virus white [DOI] 10.1111/irv.13040 PMC 바로가기